Naproxen vs Tylenol: Which Pain Reliever Is Right for You?

When you’re dealing with pain, you want something that works—fast and safely. naproxen, a nonsteroidal anti-inflammatory drug (NSAID) used for pain, swelling, and fever. Also known as Aleve, it’s the go-to for arthritis, muscle strains, and menstrual cramps. On the other side, Tylenol, the brand name for acetaminophen, a pain reliever and fever reducer without anti-inflammatory effects. Also known as paracetamol, it’s the go-to for headaches, colds, and when you can’t take NSAIDs. These two are everywhere, but they’re not the same—and picking the wrong one can make your pain worse or even hurt your health.

Here’s the real difference: naproxen fights inflammation. If your knee is swollen, your back is stiff from overuse, or your period cramps feel like a vice, naproxen tackles the root cause. Tylenol? It just dulls the signal to your brain. No swelling reduction. No anti-inflammatory punch. But if you have a sensitive stomach, kidney issues, or take blood thinners, Tylenol is often the safer pick. Naproxen can irritate your gut, raise blood pressure, and stress your kidneys. Tylenol? It’s gentle on your stomach—but overdose it, even by a little, and you can damage your liver. That’s why dosing matters. One extra pill a day, over weeks, can sneak up on you.

People often grab Tylenol because they think it’s "milder." But mild doesn’t mean harmless. And naproxen isn’t a magic bullet—it’s not great for everyday headaches or fever unless inflammation is involved. If you’re treating a sprain or tendonitis, naproxen wins. If you’ve got a fever from the flu or a headache from stress, Tylenol does the job without the risk. Some folks even alternate them for better control, but that’s something to talk to a pharmacist about first. Neither fixes the cause, but they can help you get through the day.

What you’ll find below are real comparisons from people who’ve been there: how naproxen stacks up against Tylenol for back pain, migraines, post-surgery recovery, and even long-term use. We’ve got stories from folks who switched because one made them sick, others who saved money by choosing generic versions, and people who learned the hard way why timing and dosage matter. No fluff. No marketing. Just what works—and what doesn’t—based on actual use.